Endocrine Abstracts

Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce IL-6 secretion from adipocytes. Leptin is the main secretory protein from adipose tissue. Our aim was to evaluate the acute effect of rhTSH-induced TSH surge on serum leptin levels in differentiated thyroid carcinoma (DTC) patients. Ten patients (2 m, 8 f; age range 31–66 years) with stage 1-3 DTC were evaluated during scheduled standard rhTS...

Germline point mutations of the RET proto-oncogene are causative of hereditary MTC. Somatic mutations are described in 40% of sporadic MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial.No date on the prognostic value of RET polymorphisms are available.Aim of the work was to verify if the presence of a somatic RET mutation and or a polymorphisms can influence the prognosis of MTC. This stu...